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Congratulations to HUM for completing their clinical trial with Citruslabs

HUM's Flatter Me is Effective at Reducing Bloating

Bloating and stomach distension are common problems experienced by individuals. Research has noted these adverse gastrointestinal outcomes are likely due to an imbalance or a lack of digestive enzymes to break down food in the gastrointestinal tract.  HUM developed Flatter Me to supply 18 full-spectrum enzymes to aid in breaking down food to support healthy digestion.

To understand the effectiveness of their supplement, HUM decided to run a clinical trial with Citruslabs. 

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About HUM

You feeling good--it's their mission

HUM’s mission is to help you find your confidence and feel good in your skin and body. For them, it’s about always producing unique, ultra-targeted products formulated with verified clean ingredients and clinically tested actives to help you reach your wellness goals.

Over the years, HUM has evolved with more research, products dedicated to women’s health–at every stage in her life, more innovation, and a strong, supportive community. Because of their genuine passion for problem-solving, HUM has become a wellness pioneer with an optimistic approach to struggles and a promise of life-changing science.

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The product

Flatter Me ingredients include:

  • 18 digestive enzymes that break down carbohydrates, fiber, lactose, protein, and fats

  • Ginger

  • Peppermint leaf

  • Fennel seed

What sets this product apart:

  • Flatter Me is one of the top-selling products. There is compelling anecdotal evidence from consumer reviews that the product supports digestion that contributes to reduced physical symptoms of bloating

Study design


HUM's Flatter Me supplement

In this trial, we tested HUM's Flatter Me vs. placebo in a two-visit study. Negative digestive symptoms were measured via stomach distension measurements and by participant self-report. This trial aimed to examine the efficacy of HUM's Flatter Me at reducing negative digestive symptoms (i.e., stomach distension and bloating) after consuming a meal.


Participants fasted before arriving at the lab. Both visits were blinded, so the participants did not know which visit they took the test product and which visit they took the placebo. Before eating the test meal (cheese pizza) or consuming the test product, participants answered questions on a baseline survey and took baseline waist measurements. Participants consumed either the dietary supplement or the placebo within 30 minutes of consuming the test meal.


After taking either Flatter Me or the placebo, participants answered survey questions and had waist circumference measured 30 and 90 minutes after the meal. The purpose of the waist circumference is to assess for distension and bloating at both stages. The survey questions focused on commonly experienced negative symptoms associated with gastrointestinal health (i.e., bloating and stomach distension).

The participants

The study consisted of 20 participants between the ages of 18 and 45 who self-reported bloating or stomach distension at least once daily after eating meals. Participants were excluded from the trial if they took any medication meant to treat gut health, fluid balance, or had taken any antibiotics recently. Participants were also excluded if they had a disease that affects the gastrointestinal tract, such as chronic constipation, IBS, GERD, Crohn's Disease, ulcerative colitis, celiac disease, or liver disease.


Participants experienced a significant reduction in bloating when using Flatter Me compared to the placebo

Reduced bloating, less stomach discomfort, less stomach distension, and reduced indigestion

Results: Participants had their waist circumference measured before eating the test meal, 30 minutes after eating the test meal, and 90 minutes after eating the test meal during both visits to the lab. These measurements were used to calculate difference scores to examine differences in waist circumference from baseline to 30 and 90 minutes post-test meals.

There was a statistically significant difference at both 30 and 90 minutes post-meal. Specifically, participants had less bloating when using Flatter Me compared to the placebo 30 minutes after eating the test meal. Ninety minutes after the test meal, participants who used Flatter Me experienced less bloating compared to the placebo condition. At both measurement time points, using Flatter Me led to significantly less bloating.


At 30 and 90 minutes post-meal, participants were asked to rate the severity of their bloating, distended stomach, gas, and indigestion.  Participants rated this on a 1 (absent) to 4 (severe) scale. On average, participants were more positive about Flatter Me than the placebo


This study provides evidence of the effectiveness of HUM's Flatter Me in significantly reducing bloating after meals

The main aim of this trial was to assess the efficacy of HUM's Flatter me at reducing bloating and stomach distension via stomach measurements. Participants were significantly more likely to want to continue taking Flatter Me compared to the placebo.

58% less bloating 30 minutes after a meal

68% less bloating 90 minutes after a meal

65% of participants felt less stomach discomfort after eating a meal compared to how they normally feel

65% of participants wanted to continue to use the product after a single dose

55% of participants felt less gassy than normal when taking Flatter Me

55% of participants felt Flatter Me helped with digestion


Overall, participants experienced a significant reduction in bloating when using Flatter Me compared to the placebo condition in this trial. On average, participants had a positive experience with the supplement and wanted to continue using the supplement. This controlled, well-designed study provides ample evidence of the effectiveness of the test product. 

About Citruslabs

Clinical trials for consumer brands 

Citruslabs’ mission is to provide robust, affordable clinical trials for your brand. We are setting new standards for creating research-backed product claims for supplements, skincare products, devices, CBD products, health foods, and superfoods.

We can do it all

Study design

IRB process

Patient recruitment

Patient adherence 

Data collection

Data analysis

Product claims

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