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News: Keytruda meets primary endpoint in liver cancer trial

Merck has reported successful results from its Phase III trial of Keytruda, a liver cancer treatment. The primary goal was overall survival in Asian patients with the most common form of liver cancer, hepatocellular carcinoma.

Keytruda works by triggering T lymphocytes that could impact both tumor cells and healthy cells. The drug hinders the interaction between receptors (those denoted death receptor-1, or PD-1) and its ligands.

This treatment boosts the immune system and allows the body to fight off tumor cells.

The trial at hand addressed Keytruda's performance as compared to a placebo treatment involving sorafenib or oxaliplatin on measures of response duration and disease control rate. The study employed a randomized, placebo controlled study. The subjects in both groups received either an intravenous dose of Keytruda every 3 weeks (for up to 35 total doses) or the placebo treatments.

The trial found that Keytruda, when combined with supportive care, provided a statistically significant increase in overall survival rates versus the placebo.

The trial also met secondary endpoints of progression free survival and objective response rate.

No new safety concerns arose during the third phase of the trial.

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In addition to keeping you up to date on all things clinical trials, we also act as a digital CRO with a specific focus on patient recruitment and retention. We believe that patient recruitment and study startup (especially study design and study material) are heavily intertwined. After all, study design can make or break clinical trials, and the patient-perspective should be considered when designing studies to ensure that patient targets are met not only on time, but also on budget.

For Citruslabs, patient recruitment starts with study design and ends with trial completion. We recruit patients through our network of health apps, which enables you to connect with thousands of patients in real time. The best part: these patients are already educated and prepared for the clinical trial process.

If you’d like to hear more about what we do, go here to read about what sets us apart, or here to read what our patients have to say about us.


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