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Congratulations to Semaine for completing their clinical trial with Citruslabs

Semaine Menopause Essentials is Effective at Reducing the Frequency and Severity of Common Menopause Symptoms


Menopause and perimenopause are times of significant life transitions for women. The increased risk of cardiovascular disease, hypertension, and insulin resistance, combined with the already increasing likelihood of those conditions existing due to diet and physical activity levels, creates a potential risk to women’s health. Notably, it is likely that most women entering perimenopause and menopause are already at higher risk for cardiovascular disease, thus increasing the probability of adverse health outcomes experienced by women.  Semaine has developed a single dietary supplement that contains multiple compounds that have potent properties to help negative physiological and psychological menopause-related systems.

To understand the effectiveness of their supplement, Semaine decided to run a clinical trial with Citruslabs. 

About Semaine

Un-hate your hormones

Women's health and women's pain is still not taken seriously.

This disbelief in the reality of these experiences means that there are far too few options to treat and alleviate pain.

Semaine's mission isn't just about providing solutions to women's health that's often been overlooked, but to make sure we're shifting the paradigm in how we talk about these natural parts of women's lives. 


The product

The Retinol Serum contains:

  • Encapsulated Retinol

  • Bakuchiol

  • Licorice Root Extract (Stearyl Glycyrrhetinate)

  • Squalene

  • Bisabolol 

What sets this product apart:

  • Made locally in small batches by a women-run lab to get off the production line and onto your counter in record time

  • Housed in a recyclable glass bottle

Study design

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Each participant received 90 capsules of the dietary supplement in three jars. Participants were instructed to consume one capsule each day at the same time, with food. In order to understand the effectiveness of the test product, participants were given questionnaires. The questionnaires asked participants to rate the severity and frequency of common menopause and perimenopause symptoms.


Some symptoms included hot flashes, night sweats, sleep problems, anxiety, exhaustion, brain fog, and sexual problems. Participants rated the severity and frequency of these problems before using the test product (Baseline), and then each month during the three-month trial (Months 1, 2, and 3).


Additional questions were added to the survey in Months 1, 2, and 3 that focused on participants' direct perceptions of the test product during that period.

The participants

The study consisted of 42 female participants between the ages of 40-57 and willing to take one capsule of the test product per day orally. Women also had to self-report having moderate discomfort with perimenopause or menopause symptoms. In order to determine this, participants took a short survey of common symptoms associated with menopause.


Potential participants were excluded from the trial if they used medication for high blood pressure or blood thinning. Potential participants were also excluded if they were currently or previously undergoing chemotherapy, pregnant, breastfeeding, or attempting to become pregnant during the trial.


Semaine Menopause Essentials significantly reduces the frequency and severity of common menopause symptoms

All evaluated parameters showed a statistically significant improvement from baseline to completion of the trial

Results: Participants were asked to rate the frequency they experienced hot flashes, night sweats, brain fog, and losing their temper at Baseline, Month 1, Month 2, and Month 3. Overall, there was a significant reduction (improvement) in all of the symptoms examined in this trial. Hot flashes, night sweats, brain fog, and experiencing rapid temper changes all decreased significantly across the trial, indicating that the test product was effective at improving the frequency that women experience common menopause complaints.

This reduction in symptom severity is both impressive and can lead to the conclusion that women who use the test product are likely to have a significant reduction in the symptoms related to menopause that impact their perceptions of health.

Participants were asked to rate their perception of the test product on many of the same outcomes after using it for one, two, and three months. Overall, participants viewed the in a very positive light across the trial.


This study provides evidence of the effectiveness of Semaine's Menopause Essentials in significantly improving overall health by reducing menopause symptoms

The purpose of this exploratory observation trial was to examine Menopause Essentials, created to relieve common symptoms related to menopause, over a three-month trial period.

After three months...

91% of participants would recommend using the product to a friend

81% of the participants wanted to continue using the product after three months of use

88% of participants believed the product improved their night sweats

74% believed the product improved their brain fog

83% of participants believed the product reduced their hot flashes


Semaine Menopause Essentials was developed to combine supplements that have previously demonstrated efficacy at alleviating common menopause symptoms into a single supplement. The results from this trial demonstrated that participants had significant improvements in the frequency and severity of common menopause symptoms while using Menopause Essentials. 

About Citruslabs

Clinical trials for consumer brands 

Citruslabs’ mission is to provide robust, affordable clinical trials for your brand. We are setting new standards for creating research-backed product claims for supplements, skincare products, devices, CBD products, health foods, and superfoods.

We can do it all

Study design

IRB process

Patient recruitment

Patient adherence 

Data collection

Data analysis

Product claims

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