Congratulations to Poppi for completing a clinical trial with Citruslabs
All-natural drink for Gut health and better digestion

Poppi investigated their natural apple cider vinegar soft drink as an alternative to poor-tasting vinegar supplements in the hopes of addressing bowel discomfort and bloating. The inclusion of apple cider vinegar was predicted to address common gut issues as well as improve skin health. Apple cider vinegar (ACV) is a centuries-old homeopathic remedy, and there’s about one tablespoon of it in every can of Poppi. It's pure and unfiltered, so it contains the “mother,” as well as polyphenols and prebiotics from pectin.
To test the effectiveness of their drink, Poppi decided to enroll it in a clinical trial with Citruslabs.
About Poppi
Natural solution offers relief for chronic digestion issues
Poppi is founded by husband and wife team Allison and Stephen, who created their flavored soda after Allison discovered how healing apple cider vinegar (ACV) was for her chronic digestion issues. The pair sought ways to make the prebiotic powerhouse ingredient more palatable and accessible for a wider range of people, and their naturally flavored fruit and ACV soda was born.
Poppi's soft drink addresses common digestive concerns, like bloating, gassiness, and general discomfort. Their formula is targeted at improving gut health and supporting the body through the beneficial prebiotics in ACV, without the overpowering taste.
Poppi has successfully launched a range of different flavors available for sale online, at Walmart, Target, Whole Foods, and other supermarket chains. and decided to keep up the momentum with clinical research through Citruslabs. Their goal is to deliver scientifically informed formulas to their customer base and create claims based on the product's actual performance on real people.
The product
Poppi developed their own ACV-containing prebiotic soda composed of sparkling filtered water, apple cider vinegar, fruit juice, organic cane sugar, natural flavors and stevia. The goal of this prebiotic soda is to provide an enjoyable ACV supplement beverage that addresses the unfavourable taste profile of ACV that may discourage consumer use.
Poppi Soft Drink -- ingredients
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Study design
This was a single-arm observational study over four weeks. Each day for the duration of the study, participants drank one 12 OZ can of Poppi in the morning, afternoon, or at lunch. Participants completed a survey at baseline, week two, and week four to provide information about their perceived gut health, skin health and overall experience with the product.
The participants
30 male and female participants, aged 18+, completed the study. Participants needed to have a BMI under 30 and self-reported regular issues with IBS and/or poor digestion symptoms, including bloating, gassiness, heartburn, abdominal pain, constipation, or associated symptoms. All participants were generally healthy and avoided drinking other sodas or using gut-related supplements for the duration of the study.
Abstract
Quantifying Poppi's gut-healing soft drink
This observational study conducted with Poppi is a great first step and foundational for their research. It established a baseline for their product's effects and performance. The next step for the brand would be to invest in a double-blind placebo-controlled study, the gold standard for clinical research.
Aims & Objectives: To evaluate the effects of Poppi's natural ACV soft drink on symptoms of IBS and/or poor digestion symptoms, including bloating, gassiness, heartburn, abdominal pain, constipation or associated symptoms.
Study design: Interventional and observational.
Methods: A total number of 30 male and female participants completed the study across 4 weeks, consuming one can of Poppi each day in the morning, afternoon, or at lunch. The participants were surveyed using an extensive questionnaire at baseline and weeks two and four and were asked to report any adverse effects in addition to any benefits noticed throughout the study.
Results: After consuming Poppi the majority of participants noticed improvements in bloating, gassiness, upper GI irritation, bowel sensitivity, and other digestion issues. Further, participants largely reported improved skin health and appearance after four weeks of Poppi.
Conclusion: Poppi's ACV soft drink significantly reduces the severity and frequency of gastrointestinal symptoms,
and improves skin health.
Results
Poppi's natural ACV soda significantly improved digestive symptoms in participants
This single-group study demonstrated the efficacy of Poppi's ACV soda in reducing IBS symptoms, bloating, gassiness, heartburn, and other self-reported digestive issues. Additional benefits were found in participants' skin tone and texture.
Poppi significantly improves bowel and upper GI symptoms in participants with digestion complaints, and may further work to improve complexion and skin concerns such as acne.
About Citruslabs
Clinical trials for consumer brands
Citruslabs’ mission is to provide robust, affordable clinical trials for brands. We are setting new standards for creating research-backed product claims for supplements, skincare products, devices, CBD products, health foods, and superfoods.
Citruslabs’ mission is to provide robust, affordable clinical trials for brands. We are setting new standards for creating research-backed product claims for supplements, skincare products, devices, CBD products, health foods and superfoods.
We can do it all
Study design
IRB process
Patient recruitment
Patient adherence
Data collection
Data analysis
Product claims