The current state of Hypertension clinical trials

Today, we will be rounding up some of the most recent clinical studies into high blood pressure. Given the prevalence and severity of high blood pressure in the US, it’s important to recognize what the latest clinical trials into this condition are aimed at.


1. One clinical trial that has recruited across Europe, the UK, and the US, is the CALM-2 trial (Controlling And Lowering blood pressure with MobiusHDÒ) which is based out of California, at Vascular Dynamic Incorporated. This trial started to gain traction in 2019, when clinical trials began for the endovascular approach to drug-resistant high blood pressure. The method involves a catheter-based placement of the MobiusHD implant, which utilizes the heart’s baroreceptor mechanism to address uncontrolled hypertension.


2. Currently recruiting, the MAC Clinical Research in the UK is investigating a new drug to treat hypertension in adults, and involves 18 outpatient check ups over a period of 18 months. The trial hopes to ascertain the safety and efficacy of a new drug in comparison to existing treatments for high blood pressure.


3. Also ongoing is the RADIANCE II study -- which involves an ultrasound, renal denervation procedure to treat high blood pressure. The technology involved could potentially present a non-drug treatment option, and works by disrupting the renal sympathetic nerves through ultrasound stimulation (called ReCor technology.)


Diagram created by Cardiovascular and Interventional Radiological Society of Europe

Among these trials, a common theme for the current state of high blood pressure research is evident: drug-based treatment options do not work for everyone, and both new kinds of medication, and technological alternatives are becoming increasingly popular in clinical research. Further research is needed into alternatives to drug therapies, and the results of these trials should provide some insight into the effectiveness of these kinds of treatment methods.



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