top of page

Lilly completes Phase II of Alzheimer's trial

In a study dubbed Trailblazer-Alz, Eli Lilly and Company have completed Phase II of their clinical trial examining the antibody, Donanemab, for its efficacy in slowing the decline of patients with early symptomatic Alzheimer’s disease.

Donanemab is designed to target a modified beta-amyloid, N3pG, and appears to aid in the clearance of amyloid plaque. The patients given the treatment showed an 84 centiloid decrease of amyloid plaque after 76 weeks, after beginning with a baseline of 108 centiloids. (Less than 25 centiloids would place patients in a normal range for a negative amyloid scan.)

Image by Robina Weermeijer via. Unsplash

The study’s results are promising, as they showed a significant level of amyloid plaque clearance. The trial’s clinical protocol involved multiple centers, and examined 272 patients using a randomized, placebo controlled, double-blind method. The study demonstrated a slowed decline of 32% when compared to the groups receiving the placebo. This meets the primary endpoint for 76 week changes as described in the Integrated Alzheimer’s Disease Rating Scale, and the treatment made consistent progress in all preregistered secondary endpoints such as those looking at cognition and mental function. Though, the study has not found nominal statistical significance on every secondary endpoint.

In an interview with Biospace Lilly’s chief scientific officer said: “In conjunction with our expertise in amyloid and tau imaging, this allowed us to conduct a trial to test if reducing amyloid plaques in Alzheimer’s patients to levels seen in scans of healthy individuals could result in clinically meaningful slowing of cognitive decline.”

The company intends to advance its research in a follow-up trial, Trailblazer-Alz 2.

Stay up to date on clinical trial news

Citrus is a fully integrated recruitment and retention software that fits any clinical trial and simplifies the implementation of patient engagement in your clinical trial. Whether you are already working with CTMS systems or not, Citrus is the perfect add-on to make patient interaction effective.

Since 2015, our team has been hard at work raising awareness of clinical trials across the globe. A Forbes ‘30 Under 30’ company and a graduate of the renowned Techstar program in New York, Citruslabs is at the forefront of patient recruitment and retention technologies. With over 3 million patients now recorded on our databases, our patient recruitment dashboard is fast becoming the most efficient method of trial recruitment.

Now a #1 health app in 17 countries, our Mindmate app is helping to revolutionize the way we think about healthcare. Mindmate “[takes] senior care into the digital age” (Forbes, 2018) by providing people with cognitive decline the essential tools to help them rebuild and maintain strong mental health. Trusted by millions of users, our health community continues to grow as the content available expands to the needs of individuals today.

With more than 200 research sites now using the Citrus platform to screen thousands of patients every month, researchers are now well on their way to finding new treatments for hundreds of different health conditions - something that just would not be possible without a technological solution. Make sure that your clinical trial is in the lucky 12% and turn that luck into guaranteed results with Citrus.

Still a little unsure? Check out what our customers have to say about us here.

And If you’d like to know more about how Citruslabs can help you recruit more effectively, get in touch with our team here.


bottom of page