News: BMS’ ulcerative colitis trial fails to meet efficacy goals

Bristol Myers Squibb (BMS) had been trialing deucravacitinib as an ulcerative colitis treatment, however, they have recently announced it failed to meet their primary and secondary efficacy goals.


During Phase II of the LATTICE-UC clinical trial, assessed the safety and efficacy of the treatment, and failed to meet the goals of clinical remission according to a 12 week May score.


The secondary goals of the trial looked at a clinical response via. Endoscopic response and histological improvement across the same timeline.


The treatment itself is an orally delivered drug, which is known as a selective tyrosine kinase 2 inhibitors. The treatment acts on TYK2 to hinder signaling in the body that is linked to various immune-mediated diseases, such as ulcerative colitis.


Moving forward, the treatment will be further explored in a Phase III trial aimed at using deucravacitinib as a treatment for psoriatic arthritis, which has previously proven to be effective.


The chief medical officer at BMS said in an interview with Clinical Trials arena, “While we did not achieve proof of concept in this study, we are committed to advancing our deucravacitinib clinical program in inflammatory bowel disease, including ulcerative colitis and Crohn’s disease, as well as in psoriatic arthritis, lupus and other immune-mediated diseases.”


The treatment still proved to be safe and tolerable, with no new reported adverse effects. The company is also running another Phase II trial to test a higher dose in patients with moderate to severe UC.


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